Correction: Direct oral anticoagulants versus warfarin: is new always better than the old?
ثبت نشده
چکیده
Professor Sir John Burn is Professor of Clinical Genetics at Newcastle University and a non-executive director of NHS England where at the time of submission he was deputy chair of Specialised Commissioning at NHS England. He helped write the 2003 government White Paper on Genetics which used warfarin genotyping as an example of future deployment of Pharmacogenetics. He has been working for 10 years with a small biotechnology company called QuantuMDx Ltd, based in Newcastle, to develop point of care DNA diagnostic devices. He is now employed part time as medical director and Chair and hold shares in the company. He chose warfarin genotyping as a suitable target for development of a disposable diagnostic cassette for use in clinic. This is expected to enter trials in the next 12 months.
منابع مشابه
Direct oral anticoagulants versus warfarin: is new always better than the old?
About 1.4 British million people are at risk of strokes due to non-valvular atrial fibrillation (AF) necessitating long-term anticoagulation. The vitamin K antagonist, warfarin, has a long half-life and narrow therapeutic range necessitating regular monitoring and is a common cause of iatrogenic hospital admission. Direct-acting oral anticoagulants (DOACs), dabigatran, rivaroxaban, apixaban and...
متن کاملComparison of Dabigatran vs. Warfarin in Acute Vnous Thromboemboly: Systematic Review
abstract:Acute Venous Thromboembolism (VTE) is a common disease associated with the significant morbidity and mortality. We reviewed clinical outcomes systematically with Dabigatran as a direct oral anticoagulants (DOAC) for treatment of acute VTE. We used Ovide, PubMed, Cochrane (CENTRAL), EMBASE, Scopus, Science Direct, LILAC(for article written not English) and also Iranian database; Magiran...
متن کاملComparison of Dabigatran vs. Warfarin in Acute Vnous Thromboemboly: Systematic Review
abstract:Acute Venous Thromboembolism (VTE) is a common disease associated with the significant morbidity and mortality. We reviewed clinical outcomes systematically with Dabigatran as a direct oral anticoagulants (DOAC) for treatment of acute VTE. We used Ovide, PubMed, Cochrane (CENTRAL), EMBASE, Scopus, Science Direct, LILAC(for article written not English) and also Iranian database; Magiran...
متن کاملCritique of apixaban versus warfarin in patients with atrial fibrillation.
For stroke prevention in atrial fibrillation (AF), warfarin has been the king of the castle for more than half a century. Recently, some serious contenders have threatened its dominance by claiming therapeutic equivalence and a better benefit–risk profile. These novel agents, oral direct thrombin or factor Xa inhibitors, have kindled anticipation of “a new era for anticoagulation in AF.”1 On Au...
متن کاملPossible failure of novel direct-acting oral anticoagulants in management of pulmonary embolism: a case report
BACKGROUND The relative effectiveness of vitamin K antagonists compared with novel oral anticoagulants in treating pulmonary embolism remains unclear. Recent trials comparing the efficacy of vitamin K antagonists with factor Xa inhibitors for the treatment of pulmonary emboli have been non-inferiority studies based primarily on risk reduction (such as bleeding events), rather than resolution of...
متن کامل